Multigram-Scale Synthesis and Study of Reactivity of Two Difluoromethylating Reagents Based on Sulfoximine Skeletons
Hu’s reagent is widely known for the electrophilic and radical difluoromethylation reactions of various compounds of interest for the pharmaceutical and agrochemical fields. Recently, our group described a cyclic version of this sulfoximine. In this article, the gram-scale synthesis of these two reagents, as well as a comparison of their reactivity in electrophilic and radical transformation, is disclosed. DSC and TGA measurements were carried out on the pure final compounds to assess the safety of the process.
Authors
- Nathalie Leclerc (ORCID: https://orcid.org/0000-0001-9050-8753)
- Guillaume Dagousset (ORCID: https://orcid.org/0000-0001-8720-3828)
- Bruce Pégot (ORCID: https://orcid.org/0000-0001-5137-5548)
- Elsa Anselmi (ORCID: https://orcid.org/0000-0003-2996-2775)
- Marina Briand
- Emmanuel Magnier (ORCID: https://orcid.org/0000-0003-3392-3971)
- Gabriel Goujon
Institutions
- Université de Tours (FR)
- Université de Versailles Saint-Quentin-en-Yvelines (FR)
- Université Paris-Saclay (FR)
- Institut Lavoisier de Versailles (FR)
Publication Details
- Journal
- Organic Process Research & Development
- Published
- 2025-06-13
- DOI
- https://doi.org/10.1021/acs.oprd.5c00148
- Primary Topic
- Fluorine in Organic Chemistry
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Centre National de la Recherche Scientifique
- Université de Versailles Saint-Quentin-en-Yvelines