Micro-CT and histological evaluation of alveolar ridge preservation with Bio-Oss® and THE Graft®: A randomized controlled trial

This randomized clinical trial aimed to compare volumetric changes and histological characteristics of new bone in extraction sockets grafted with Bio-Oss® or THE Graft®. Furthermore, it sought to further assess the quality and quantity of bone regeneration at 3- and 6-months. Thirty-two patients requiring single-tooth extraction (excluding third molars) and ridge preservation in preparation for implant placement were randomized to receive either graft material (Bio-Oss® or THE Graft®) covered by a collagen membrane. At 3 months, BV/TV was higher in the DBBM groups than in the DPBM groups, while mineralized bone proportions were similar between groups. By 6 months, BV/TV remained significantly higher in DPBM groups than in the DBBM groups, and higher proportion of mineralized bone was observed in the DPBM groups. Both groups showed increasing BV/TV and mineralized bone over time. In conclusion, both Bio-Oss® and THE Graft® effectively promoted socket bone regeneration, with healing time influencing formation. Long-term results suggest THE Graft® may enhance mineralized bone percentage more than Bio-Oss®. • Both Bio-Oss® and THE Graft® effectively promote bone regeneration in extraction sockets. • Healing duration significantly affects tissue composition in post-extraction sites. • THE Graft® could product higher mineralized bone proportions compared to Bio-Oss®. • Highlighting the importance of graft material selection and healing time.