The Oral Microbiome and All-Cause Mortality in a US Population-Representative Prospective Cohort
No large studies have evaluated whether the human oral microbiome is directly associated with mortality. We evaluated prospective associations between the oral microbiome, measured using 16S ribosomal RNA gene sequencing, from participants aged 20-69 years in the 2009-2012 cycles of the National Health and Nutrition Examination Survey (NHANES) and all-cause mortality (N = 7721, representing ∼194 million individuals). Alpha diversity was inversely associated with mortality, and some significant associations were observed with the beta diversity matrices. Higher relative abundances of Granulicatella and Lactobacillus were associated with increased risk, while Bacteroides was associated with decreased all-cause mortality at the genus level. Results suggest that oral bacterial communities may be important contributors to health and disease.
Authors
- Nicholas A. Bokulich (ORCID: https://orcid.org/0000-0002-1784-8935)
- Yukiko Yano (ORCID: https://orcid.org/0000-0001-9816-0384)
- Shilan Li (ORCID: https://orcid.org/0000-0002-1132-1550)
- Lisa Kahle (ORCID: https://orcid.org/0000-0002-1783-7240)
- Christian C. Abnet (ORCID: https://orcid.org/0000-0002-3008-7843)
- Anil K. Chaturvedi (ORCID: https://orcid.org/0000-0003-2696-8899)
- Xing Hua (ORCID: https://orcid.org/0000-0002-8346-5887)
- Yunhu Wan (ORCID: https://orcid.org/0000-0002-6556-0602)
- Martin J. Blaser (ORCID: https://orcid.org/0000-0003-2447-2443)
- Rob Knight (ORCID: https://orcid.org/0000-0002-0975-9019)
- J. Gregory Caporaso (ORCID: https://orcid.org/0000-0002-8865-1670)
- Vaishnavi Purandare
- Barry I. Graubard (ORCID: https://orcid.org/0000-0002-6787-1105)
- Maura L. Gillison (ORCID: https://orcid.org/0000-0002-8145-5749)
- Emily Vogtmann (ORCID: https://orcid.org/0000-0003-1355-5593)
- Autumn G. Hullings (ORCID: https://orcid.org/0000-0003-3400-7887)
- Neal D. Freedman (ORCID: https://orcid.org/0000-0003-0074-1098)
- Jody McLean (ORCID: https://orcid.org/0000-0002-2709-9181)
- Jianxin Shi (ORCID: https://orcid.org/0000-0001-8606-4707)
Institutions
- Rutgers, The State University of New Jersey (US)
- University of North Carolina at Chapel Hill (US)
- Leidos (United States) (US)
- Centers for Disease Control and Prevention (US)
- National Center for Health Statistics (US)
- The University of Texas MD Anderson Cancer Center (US)
- Johns Hopkins University (US)
- Northern Arizona University (US)
- Johns Hopkins Medicine (US)
- ETH Zurich (CH)
- University of California San Diego (US)
- Information Management Services (US)
- Department of Medical Sciences (BY)
- Frederick National Laboratory for Cancer Research (US)
- National Cancer Institute (US)
- Leidos Biomedical Research Inc. (United States)
Publication Details
- Journal
- The Journal of Infectious Diseases
- Published
- 2025-06-13
- DOI
- https://doi.org/10.1093/infdis/jiaf321
- Citations
- 2
- Primary Topic
- Oral microbiology and periodontitis research
- Type
- article
- Field-Weighted Citation Impact
- 2.93
Funders
- Uniwersytet Szczeciński
- National Institutes of Health
- National Institute of Dental and Craniofacial Research