Outcomes of Frontline Triplet Regimens With a Hypomethylating Agent, Venetoclax, and Isocitrate Dehydrogenase Inhibitor for Intensive Chemotherapy–Ineligible Patients With Isocitrate Dehydrogenase–Mutated AML
Given the excellent outcomes of IDH-triplet therapy for newly diagnosed, IC-ineligible <i>IDH</i>-mutant AML, further prospective studies comparing IDH-triplet versus IDH-doublet regimens are warranted.
Authors
- Farhad Ravandi (ORCID: https://orcid.org/0000-0002-7621-377X)
- Jennifer Marvin‐Peek (ORCID: https://orcid.org/0000-0001-9595-1279)
- Courtney Denton Dinardo (ORCID: https://orcid.org/0000-0001-9003-0390)
- Wei‐Ying Jen (ORCID: https://orcid.org/0000-0002-9339-3362)
- Fadi Haddad (ORCID: https://orcid.org/0000-0002-9702-8485)
- Steven Mitchell Kornblau (ORCID: https://orcid.org/0000-0002-5990-9548)
- Tapan Mahendra Kadia (ORCID: https://orcid.org/0000-0002-9892-9832)
- Marina Konopleva (ORCID: https://orcid.org/0000-0002-9347-2212)
- Corey Bradley (ORCID: https://orcid.org/0000-0002-3988-1023)
- Guillermo Montalban‐Bravo (ORCID: https://orcid.org/0000-0002-4533-5176)
- Kelly Sharon Chien (ORCID: https://orcid.org/0000-0001-6024-1613)
- Koji Sasaki (ORCID: https://orcid.org/0000-0002-9140-0610)
- Patrick K. Reville (ORCID: https://orcid.org/0000-0001-8433-3360)
- Naval Guastad Daver (ORCID: https://orcid.org/0000-0001-7103-373X)
- Elias Joseph Jabbour (ORCID: https://orcid.org/0000-0003-4465-6119)
- Musa E. Yilmaz (ORCID: https://orcid.org/0000-0002-4498-4895)
- Koichi Takahashi (ORCID: https://orcid.org/0000-0002-8027-9659)
- Gautam M. Borthakur (ORCID: https://orcid.org/0000-0001-7679-6453)
- Sanam Loghavi (ORCID: https://orcid.org/0000-0001-8980-3202)
- Ghayas C. Issa (ORCID: https://orcid.org/0000-0002-4339-8683)
- Guillermo Garcia‐Manero (ORCID: https://orcid.org/0000-0002-3631-2482)
- Yesid Alvarado (ORCID: https://orcid.org/0000-0002-1652-7937)
- Hussein A. Abbas (ORCID: https://orcid.org/0000-0003-2946-3562)
- Abhishek Maiti (ORCID: https://orcid.org/0000-0001-9043-538X)
- Danielle Hammond (ORCID: https://orcid.org/0000-0002-6017-2264)
- Naveen Pemmaraju (ORCID: https://orcid.org/0000-0002-1670-6513)
- Hagop M. Kantarjian (ORCID: https://orcid.org/0000-0002-1908-3307)
- Nicholas James Short (ORCID: https://orcid.org/0000-0002-2983-2738)
- Jillian Mullin
Institutions
- Albert Einstein College of Medicine (US)
- Montefiore Medical Center (US)
- The University of Texas MD Anderson Cancer Center (US)
- Montefiore Einstein Comprehensive Cancer Center
Publication Details
- Journal
- Journal of Clinical Oncology
- Published
- 2025-06-13
- DOI
- https://doi.org/10.1200/jco-25-00640
- Citations
- 16
- Primary Topic
- Acute Myeloid Leukemia Research
- Type
- article
- Field-Weighted Citation Impact
- 28.32