Optimization of Teicoplanin Dosing Regimen in Adult Patients Using an Externally Evaluated Population Pharmacokinetic Model

By combining external evaluations using Nonlinear Mixed-Effects Modeling with Monte Carlo simulations, the model developed by Ogami et al was identified as the most suitable for guiding clinical dosing under different pathophysiological conditions.

Authors

Zhikun Xun
Baiqian Xing
Genzhu Wang
Zhongdong Li (ORCID: https://orcid.org/0000-0003-0382-3136)
Xiaoying Wang (ORCID: https://orcid.org/0000-0001-9822-961X)
Qiang Sun (ORCID: https://orcid.org/0000-0002-6703-1587)
Xiaojing Li (ORCID: https://orcid.org/0009-0007-9405-5019)

Institutions

State Grid Corporation of China (China) (CN)
E Ink (South Korea) (KR)

Publication Details

Journal: Therapeutic Drug Monitoring
Published: 2025-06-13
DOI: https://doi.org/10.1097/ftd.0000000000001349
Primary Topic: Antibiotics Pharmacokinetics and Efficacy
Type: article
Field-Weighted Citation Impact: 0.00

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article

Optimization of Teicoplanin Dosing Regimen in Adult Patients Using an Externally Evaluated Population Pharmacokinetic Model

Zhikun Xun, Baiqian Xing, Genzhu Wang, Zhongdong Li et al.

Jun 13, 2025

Therapeutic Drug Monitoring

Antibiotics Pharmacokinetics and Efficacy

article

Optimization of Teicoplanin Dosing Regimen in Adult Patients Using an Externally Evaluated Population Pharmacokinetic Model

Zhikun Xun, Baiqian Xing, Genzhu Wang, Zhongdong Li, Xiaoying Wang, Qiang Sun, Xiaojing Li

June 13, 2025article en

Abstract

By combining external evaluations using Nonlinear Mixed-Effects Modeling with Monte Carlo simulations, the model developed by Ogami et al was identified as the most suitable for guiding clinical dosing under different pathophysiological conditions.

Therapeutic Drug MonitoringVol. 47(6)

State Grid Corporation of China (China) (CN), E Ink (South Korea) (KR)

Openalex Percentile: Top 85%

Antibiotics Pharmacokinetics and Efficacy

DOI Source OpenAlex

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Optimization of Teicoplanin Dosing Regimen in Adult Patients Using an Externally Evaluated Population Pharmacokinetic Model — Zhikun Xun, Baiqian Xing, et al. · Therapeutic Drug Monitoring (2025) | TGRS Research Map | TGRS