Adoptive Cell Transfer of Tumor-Infiltrating Lymphocytes for Metastatic Acral Lentiginous Melanoma
ACT-TIL can mediate objective responses in patients with metastatic acral melanoma, and outcomes in patients with acral disease were unexpectedly comparable with those of contemporaneously treated patients with nonacral cutaneous melanoma. Further research is necessary to understand the immunologic basis of responses to ACT-TIL in acral melanoma and to increase the frequency of CRs.
Authors
- Jared J. Gartner (ORCID: https://orcid.org/0000-0003-2924-3519)
- Mei Li M. Kwong (ORCID: https://orcid.org/0000-0003-1265-520X)
- Sivasish Sindiri (ORCID: https://orcid.org/0000-0003-2516-969X)
- Shirley Nah (ORCID: https://orcid.org/0000-0002-0916-1025)
- Paul H. McClelland (ORCID: https://orcid.org/0000-0002-3119-6531)
- Nicholas D. Klemen (ORCID: https://orcid.org/0000-0003-1353-539X)
- Billel Gasmi (ORCID: https://orcid.org/0000-0002-8061-8278)
- Paul F. Robbins (ORCID: https://orcid.org/0000-0002-1260-8123)
- Maria R. Parkhurst (ORCID: https://orcid.org/0000-0001-7231-5069)
- Aaron J Dinerman (ORCID: https://orcid.org/0009-0008-8670-8347)
- Bradley Sinclair White
- A. Gustafson (ORCID: https://orcid.org/0000-0003-4676-2097)
- Steven A. Rosenberg (ORCID: https://orcid.org/0000-0002-8939-8910)
- Todd D. Prickett (ORCID: https://orcid.org/0000-0001-5466-4150)
- Stephanie L. Goff (ORCID: https://orcid.org/0000-0003-3317-9804)
- Hyunmi Halas (ORCID: https://orcid.org/0009-0007-3933-6459)
- James C. Yang (ORCID: https://orcid.org/0000-0001-8935-5008)
- Donald White
Institutions
- National Cancer Institute (US)
Publication Details
- Journal
- Journal of Clinical Oncology
- Published
- 2025-06-13
- DOI
- https://doi.org/10.1200/jco-24-02348
- Citations
- 2
- Primary Topic
- CAR-T cell therapy research
- Type
- article
- Field-Weighted Citation Impact
- 2.09