Total Synthesis of Pedopeptin C
The pedopeptins are a class of antibiotics that have been reported to retain activity against bacterial strains that are resistant to the polymyxins, a class of antibiotics of last resort. Despite this promising activity, the pedopeptins represent synthetically challenging targets due to the dehydroamino acid (<i>E</i>)-2-aminobut-2-enoic acid ((<i>E</i>)-ΔAbu) contained in their structure. Here we show an optimized synthesis of a lead member of this class, pedopeptin C, and describe its antibacterial activity.
Authors
- Tommy Lai
- Michael J. Lambrecht
- Ying Lü (ORCID: https://orcid.org/0000-0002-8828-169X)
- Steven T. Rutherford (ORCID: https://orcid.org/0000-0002-4758-4248)
- Michael F. T. Koehler (ORCID: https://orcid.org/0000-0003-0967-8304)
- Daniel J. Burdick (ORCID: https://orcid.org/0000-0003-3475-7397)
- Qiuyue Wang
- Jiao Xu
- Mary Kate Alexander (ORCID: https://orcid.org/0009-0004-2041-5016)
- Chen Cheng (ORCID: https://orcid.org/0000-0003-3395-5375)
Institutions
- WuXi AppTec (China) (CN)
Publication Details
- Journal
- Organic Letters
- Published
- 2025-06-13
- DOI
- https://doi.org/10.1021/acs.orglett.5c01928
- Primary Topic
- Chemical Synthesis and Analysis
- Type
- article
- Field-Weighted Citation Impact
- 0.00