Palladium-Catalyzed Aminocarbonylation Using Nitroarenes under NMP-Mediated Photochemical Conditions
A photochemical approach enabling mild amide synthesis from aryl iodides, carbon monoxide, and nitroarenes at 25 °C under 1 atm of CO is disclosed. Under a PdCl<sub>2</sub>/Xantphos-FeCl<sub>3</sub> catalyst in <i>N</i>-methylpyrrolidone, broad functional group tolerance is observed. Mechanistic studies reveal that nitroarenes form a base-activated <i>N</i>-methylpyrrolidone-bound adduct, which generates an aniline-like intermediate that couples with the acyl-palladium complex to deliver the desired amides.
Authors
- Sunwoo Lee (ORCID: https://orcid.org/0000-0001-5079-3860)
- Minwoo Park (ORCID: https://orcid.org/0000-0003-4008-2816)
- Karthik Rajan Rajamanickam
Institutions
- Chonnam National University Hospital (KR)
Publication Details
- Journal
- Organic Letters
- Published
- 2025-06-13
- DOI
- https://doi.org/10.1021/acs.orglett.5c01619
- Citations
- 2
- Primary Topic
- Chemical Synthesis and Analysis
- Type
- article
- Field-Weighted Citation Impact
- 1.61
Funders
- National Research Foundation of Korea