Abstract 2957 The diversity of cell lines, does it matter if we are Black or White?

Biological model systems are fundamental for deciphering cellular mechanisms, disease pathogenesis, and drug efficacy. Human cell lines, derived from normal and diseased states, are essential for basic and translational research. However, significant variability in experimental reproducibility exists among cell lines, primarily due to differences in genetic background, including polymorphisms, epigenetic signatures, and gene expression patterns. These differences occur both within and between racial/ethnic groups.