Abstract 1090 Understanding the Role of Phosphorylation in Mitochondrial Malate Dehydrogenase Regulation

Human mitochondrial malate dehydrogenase (hMDH2) plays a central role in metabolism, catalyzing the reversible conversion of malate to oxaloacetate, while reducing NAD+. This enzyme is not only essential to the tricarboxylic acid cycle (TCA), but also features prominently in the malate-aspartate shuttle and drives oxaloacetate reduction for anaplerosis of TCA. Through these functions, hMDH2 maintains proper levels of metabolic intermediates and any dysregulation of this tightly controlled system is correlated with a variety of human conditions, such as cancer, neurological disorders, and metabolic disease.