Abstract 1168 A conserved motif of H. pylori CPA regulates oligomerization via a noncatalytic triad
N-carbamoyl putrescine amidase (CPA) is a crucial intermediate enzyme in polyamine synthesis, essential for cell growth and proliferation in plants and many bacteria. Since CPA is absent in humans, its existence in H. pylori makes it a potential therapeutic target. A five-residue motif of H. pylori 26695 CPA located near the active site is conserved in other homologs, and its residues are essential for oligomerization. This motif exists as a short helix, in contrast to in silico analysis, where it does not form a secondary structure.
Authors
- Apurba Kumar Sau (ORCID: https://orcid.org/0000-0002-5909-9442)
- Ramachandran Vijayan (ORCID: https://orcid.org/0000-0001-5788-5282)
- Ditsa Sarkar (ORCID: https://orcid.org/0000-0003-0415-5248)
- Annie Molla (ORCID: https://orcid.org/0000-0002-9859-8682)
- Tasneem Kausar
- Ashma Khan
- Samudrala Gourinath (ORCID: https://orcid.org/0000-0003-4090-3063)
Institutions
- National Institute of Immunology (IN)
Publication Details
- Journal
- Journal of Biological Chemistry
- Published
- 2025-05-01
- DOI
- https://doi.org/10.1016/j.jbc.2025.109107
- Primary Topic
- Biofuel production and bioconversion
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Institutes of Health
- National Institute of General Medical Sciences