Abstract 1075 Exploring Trypanosoma brucei NDPK: Biochemical and Structural Foundations for Targeted Drug Design

Nucleoside diphosphate kinase (NDPK) is a critical enzyme involved in nucleotide metabolism and signaling, essential for the survival and proliferation of Trypanosoma brucei. Given the lack of approved vaccines for Human African Trypanosomiasis (HAT), treatment relies heavily on drug therapies and vector control. However, existing treatments face challenges, including reduced efficacy and emerging drug resistance, making them less effective over time. Targeting key enzymes such as TbNDPK in T. brucei offers a promising avenue for developing novel therapeutic approaches to overcome the limitations of current drugs.