Abstract 1104 Identifying Native Redox Partner(s) for CYP168A1: A Cytochrome P450 from Pseudomonas aeruginosa

Pseudomonas aeruginosa is an opportunistic pathogen that is labeled a critical priority 1 risk by the WHO due to antibiotic resistance. An enzyme, CYP168A1, has expression patterns that correlate with the disease state of P. aeruginosa. Published research has shown that CYP168A1 can modify fatty acids, but little else is known about its importance to Pseudomonas. Additionally, these studies did not use native partner proteins of CYP168A1, which remain unknown. My research focuses on identifying these native partner proteins.

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Journal
Journal of Biological Chemistry
Published
2025-05-01
DOI
https://doi.org/10.1016/j.jbc.2025.109103
Primary Topic
Computational Drug Discovery Methods
Type
article
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article

Abstract 1104 Identifying Native Redox Partner(s) for CYP168A1: A Cytochrome P450 from Pseudomonas aeruginosa

Peter N. Herbert, Justin S. Miller, Adrianne Rusch
1 links
Journal of Biological Chemistry
Computational Drug Discovery Methods
article

Abstract 1104 Identifying Native Redox Partner(s) for CYP168A1: A Cytochrome P450 from Pseudomonas aeruginosa

Peter N. Herbert, Justin S. Miller, Adrianne Rusch
article en

Abstract

Pseudomonas aeruginosa is an opportunistic pathogen that is labeled a critical priority 1 risk by the WHO due to antibiotic resistance. An enzyme, CYP168A1, has expression patterns that correlate with the disease state of P. aeruginosa. Published research has shown that CYP168A1 can modify fatty acids, but little else is known about its importance to Pseudomonas. Additionally, these studies did not use native partner proteins of CYP168A1, which remain unknown. My research focuses on identifying these native partner proteins.

Journal of Biological ChemistryVol. 301(5)
Indiana State University (US)
Zero hunger
Openalex Percentile: Top 85%
Computational Drug Discovery Methods
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