Abstract 1496 Functional Characterization of a Diiron Protein: Unraveling its Role in Methanogen Oxidative Stress Response
Methanogens are key contributors to methane production in anaerobic ecosystems, accounting for around 90% methane generation and driving of anthropogenic radiative forcing. While their one-carbon metabolic pathways are well-studied, the mechanisms of redox balance and oxidative stress management remain poorly understood. Methanosarcina acetivorans, a model acetotrophic methanogen previously thought to be strictly anaerobic, can tolerate low oxygen levels (0.4–1% O2), suggesting the presence of oxygen-detoxifying enzymes.
Authors
- Ian C. B. Marshall
- Divya Prakash (ORCID: https://orcid.org/0000-0002-1408-2671)
- Amit Rai (ORCID: https://orcid.org/0000-0002-5715-8541)
- Yisong Guo (ORCID: https://orcid.org/0000-0002-4132-3565)
- Neelima Bhatt
- Wellington Leite (ORCID: https://orcid.org/0000-0002-5674-3968)
- N. Sukumar (ORCID: https://orcid.org/0000-0002-3149-9292)
- James Byrnes (ORCID: https://orcid.org/0000-0002-4906-0640)
- Jin Xiong (ORCID: https://orcid.org/0000-0001-7443-0554)
Institutions
- HaitiChildren (US)
Publication Details
- Journal
- Journal of Biological Chemistry
- Published
- 2025-05-01
- DOI
- https://doi.org/10.1016/j.jbc.2025.109125
- Primary Topic
- Porphyrin Metabolism and Disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Japan Society for the Promotion of Science