Abstract 1402 Atomic Level Mechanism of NIS Synthetases

The superfamily of adenylating enzymes includes two subfamilies of siderophore synthetases. One of them, the NIS Synthetases, is an excellent target for structure-based antibiotic drug design due to its novel structure and function, and association with virulence. The NIS synthetases are understudied, but are excellent drug targets due to their novel structure and chemistry, critical role in iron acquisition, and increasing association with virulence in bacteria. NIS Synthetases are group V adenylating enzymes, a designation that offers an intriguing comparative mechanism to explore as we seek to determine the NIS Synthetase atomic level mechanism.