Abstract 1014 A proteome-wide yeast degron collection for the dynamic study of protein function
Genome-wide collections of yeast strains, known as libraries, revolutionized the way systematic studies are carried out. Specifically, libraries that involve a cellular perturbation, such as the deletion collection, have facilitated key biological discoveries. However, short-term rewiring and long-term accumulation of suppressor mutations often obscure the functional consequences of such perturbations. We present the AID library which supplies “on demand” protein depletion to overcome these limitations.
Authors
- Angela Boshnakovska (ORCID: https://orcid.org/0009-0008-3572-0223)
- Rosario Valenti (ORCID: https://orcid.org/0000-0002-6093-1873)
- Peter Rehling (ORCID: https://orcid.org/0000-0001-5661-5272)
- Yotam David (ORCID: https://orcid.org/0000-0003-4992-7045)
- Benjamin Dubreuil (ORCID: https://orcid.org/0000-0002-8229-641X)
- Maya Schuldiner (ORCID: https://orcid.org/0000-0001-9947-115X)
- Ehud Sass (ORCID: https://orcid.org/0000-0003-4302-1496)
- Yeynit Asraf
- Dunya Edilbi
Institutions
- Weizmann Institute of Science (IL)
Publication Details
- Journal
- Journal of Biological Chemistry
- Published
- 2025-05-01
- DOI
- https://doi.org/10.1016/j.jbc.2025.109802
- Primary Topic
- Advanced Proteomics Techniques and Applications
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Minerva Foundation
- Weizmann Institute of Science