Abstract 2901 Short chain fatty acids driven histone modification and differential gene expression pattern in human colorectal cancer Cells

Short-chain fatty acids (SCFAs), defined as fatty acids with fewer than six carbon atoms, are the major group of metabolites as the end products of microbial fermentation in the gut and have important roles in human physiology. These metabolites interact with the host through various mechanisms, one of which involves altering the chromatin landscape. Previously, we identified that specific histone modifications in the mouse gut are influenced by the microbiota and the availability of SCFAs. However, the effects of SCFAs on chromatin and their impact on gene regulation in human cells remain largely unexplored.