Abstract 1787 Deciphering the Role of the Lysine-Rich Domain in Hho1: Implications for Chromatin Remodeling, Gene Regulation and Post-translational modifications

Chromatin is assembled through repeating units of nucleosomes, consisting of DNA wrapped around an octameric unit of histone proteins (H3, H4, H2A, and H2B). When DNA is associated with a nucleosome it is silenced and must be unwound from the histone proteins to be used for processes such as replication and transcription. Recent research substantiated that the linker histone, Hho1, in yeast, has an inhibitory effect on transcription. Interestingly, Hho1 has been shown to binddirectly with the RSC chromatin remodeler complex, a well-known activator of transcription.