Abstract 2420 Epigenetics: A Gatekeeper to DNA Amplification & Rearrangements

DNA amplification and rearrangements are associated with pathological states such as neurological disorders, cardiac disease and cancer. Our laboratory aims to define the principles regulating selective DNA amplification and rearrangements so we may control these events in disease. By resolving general mechanisms governing selective amplifications and rearrangements, we will build a framework to further understand the molecular basis by which these abnormalities occur in neoplasia and other diseases.