Utility of Readily Available Sugammadex for Emergent Neuromuscular Blockade Reversal

Our study found a statistically significant decrease in the time to reversal when an emergent reversal kit of six 500 mg vials is placed in an easily accessible location. The mean time for anesthesia residents to successfully reverse neuromuscular blockade was 7.7 minutes on their first attempt without the emergent reversal kit and decreased to 2.9 minutes after practice (on the third attempt). However, implementation of an emergent reversal kit resulted in further time reduction to a mean time of 2.1 minutes on their first attempt and 1.4 minutes on their second attempt when using the emergency reversal kit. These findings reinforce the importance of medication accessibility in high-stakes scenarios and provide a novel method for improving emergency preparedness in anesthesia practice.

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Publication Details

Journal
Cureus
Published
2025-06-13
DOI
https://doi.org/10.7759/cureus.85932
Primary Topic
Anesthesia and Sedative Agents
Type
article
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article

Utility of Readily Available Sugammadex for Emergent Neuromuscular Blockade Reversal

Tobias Renner, Nery Le, Kevin E. Varner, Matthias Franzen et al.
Cureus
Anesthesia and Sedative Agents
article

Utility of Readily Available Sugammadex for Emergent Neuromuscular Blockade Reversal

Tobias Renner, Nery Le, Kevin E. Varner, Matthias Franzen, Elizabeth Johnson-Gray, Austin J Shaffer
article en

Abstract

Our study found a statistically significant decrease in the time to reversal when an emergent reversal kit of six 500 mg vials is placed in an easily accessible location. The mean time for anesthesia residents to successfully reverse neuromuscular blockade was 7.7 minutes on their first attempt without the emergent reversal kit and decreased to 2.9 minutes after practice (on the third attempt). However, implementation of an emergent reversal kit resulted in further time reduction to a mean time of 2.1 minutes on their first attempt and 1.4 minutes on their second attempt when using the emergency reversal kit. These findings reinforce the importance of medication accessibility in high-stakes scenarios and provide a novel method for improving emergency preparedness in anesthesia practice.

CureusVol. 17(6)
OhioHealth (US), Osteopathic Heritage Foundation (US), Ohio University (US)
Zero hunger
Openalex Percentile: Top 76%
Anesthesia and Sedative Agents
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Utility of Readily Available Sugammadex for Emergent Neuromuscular Blockade Reversal — Tobias Renner, Nery Le, et al. · Cureus (2025) | TGRS Research Map | TGRS