Abstract 2208 Characterization of an expanded Cdc14 phosphatase family in the ciliated protozoan Tetrahymena thermophila

Cdc14 is a highly conserved protein phosphatase across eukaryotes, including humans, but notably absent in angiosperms. Initially identified in baker's yeast as a key regulator of cell division, Cdc14 plays different roles in humans. Mutations in human Cdc14A have been linked to male infertility and hearing loss due to defects in cilia maintenance and function. However, the mechanisms underlying hCdc14A's role in ciliary structure and function and why hCdc14A mutations lead to these defects remain unclear.