Abstract 2609 Investigating The Evolution of Negative Cooperativity of Phosphagen Kinases Through Stichopus japonicus Arginine Kinase (SjAK)

Arginine kinases (AK) are a subclass of phosphagen kinases (PKs) that catalyze the reversible transfer of a phosphoryl group to a phosphoarginine to maintain high concentrations of ATP. Arginine kinases can exist as a monomer or a dimer, however, the purpose of the oligomerization of the PKs evolved is not well understood. Previous comparative analyses on dimeric creatine kinases (CKs) have shown conserved residues along the subunit interface, such as R148 in Tethya aurantia CK (TaCK), which is important for dimerization.