Abstract 1798 Histone H3 N-terminal recognition by the PHD finger of PHRF1 is required for proper DNA damage response
Plant homeodomain (PHD) fingers are critical effectors of histone post-translational modifications (PTMs), acting as regulators of gene expression and genome integrity, and frequently presenting in human disease. While most PHD fingers recognize unmodified and methylated states of histone H3 lysine 4 (H3K4), the specific functions of many of the over 100 PHD finger-containing proteins in humans remain poorly understood, despite their significant implications in disease processes. In this study, we undertook a comprehensive analysis of one such poorly characterized PHD finger-containing protein, PHRF1.
Authors
- Brian D. Strahl (ORCID: https://orcid.org/0000-0002-4947-6259)
- Michael‐Christopher Keogh (ORCID: https://orcid.org/0000-0002-2219-8623)
- Matthew R. Marunde (ORCID: https://orcid.org/0009-0007-5934-7200)
- Jo Lambert (ORCID: https://orcid.org/0000-0001-5303-9310)
- Kanishk Jain (ORCID: https://orcid.org/0000-0001-8039-0464)
- Pata-Eting Kougnassoukou Tchara (ORCID: https://orcid.org/0000-0003-3524-7225)
- Christopher N. Bowman (ORCID: https://orcid.org/0000-0001-8458-7723)
- Aidan Holland
- Amanuel B. Mengistalem
Institutions
- Twin Cities Orthopedics (US)
Publication Details
- Journal
- Journal of Biological Chemistry
- Published
- 2025-05-01
- DOI
- https://doi.org/10.1016/j.jbc.2025.109261
- Primary Topic
- Cancer therapeutics and mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Institutes of Health