Abstract 2121 Traumatic Brain Injury Induces Acute Phospholipid Dysregulation in Mouse Cortex Correlative to Cognitive Impairment

Introduction: Traumatic brain injuries (TBI) are a leading cause of death and disability in the United States with limited therapeutic options available. Phospholipids, such as phosphatidylcholine, are abundant in the human cortical tissue and play important roles in the structural integrity of the blood brain barrier, neuronal and glial cells. Following perturbation of the membrane, pro-inflammatory metabolites, lysophospholipids, are produced through phospholipase activity. The mechanisms through which phospholipids and their metabolites contribute to the cognitive impairment associated with TBIs are not well known.