Abstract 1419 [PRION+] States Are Associated with Specific Histone H3 Post-Translational Modification Changes in Saccharomyces cerevisiae
Prions are proteins able to assume alternative conformations and propagate them via self-templating. In Saccharomyces cerevisiae, prions enable heritable responses to environmental conditions. Hence, [PRION+] states may serve as an atypical form of epigenetic control, producing heritable phenotypic change via protein folding. Do [PRION+] states link to canonical epigenetic channels, such as histone post-translational modifications? Via immunoblotting, we explore this question in the context of the [SWI+] and [PIN+] prion states.
Authors
- Rania Frederic
- Elizaveta Son
- Navin Rana
- Mariana P. Torrente (ORCID: https://orcid.org/0000-0001-8220-2228)
- Chaim Janani
- Samantha Cobos
- Jailene Paredes Casado (ORCID: https://orcid.org/0000-0001-5964-6517)
- Maliha Khan (ORCID: https://orcid.org/0000-0002-4516-3837)
- Gabriel Cruz
Institutions
- Purdue University West Lafayette (US)
Publication Details
- Journal
- Journal of Biological Chemistry
- Published
- 2025-05-01
- DOI
- https://doi.org/10.1016/j.jbc.2025.109238
- Primary Topic
- RNA Research and Splicing
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Purdue University