Abstract 2075 Prolonged Local Inhibition of The Neuronal Membrane Proteasome Results In Reduced Pain Sensitivity

The use of pan-proteasome inhibitors, such as those used for human cancer therapies, has been linked to development of painful peripheral neuropathy. Moreover, other studies suggest that low concentrations of these proteasome inhibitors result in reduced pain sensitivity leaving a gap in our understanding of the function of proteasomes in peripheral nerves. We recently identified the neuronal membrane proteasome (NMP) in a subpopulation of somatosensory neurons whose activity is involved in mediating pain sensitivity acutely.