Abstract 1827 The structure of DNA methyltransferase DNMT3C reveals an activity-tuning mechanism for DNA methylation
DNA methylation is one of the major epigenetic mechanisms crucial for gene regulation and genome stability. De novo DNA methyltransferase DNMT3C is required for silencing evolutionarily young transposons during mice spermatogenesis. Mutation of DNMT3C led to a sterility phenotype that cannot be rescued by its homologs DNMT3A and DNMT3B. However, the structural basis of DNMT3C-mediated DNA methylation remains unknown. Here, we report the structure and mechanism of DNMT3C-mediated DNA methylation.
Authors
- Jiuwei Lu (ORCID: https://orcid.org/0000-0002-6478-4081)
- Jikui Song (ORCID: https://orcid.org/0000-0002-4958-1032)
- Nelli Khudaverdyan
- Xinyi Chen (ORCID: https://orcid.org/0000-0002-8666-6924)
- Genevieve Herle
Institutions
- University of California, Riverside (US)
Publication Details
- Journal
- Journal of Biological Chemistry
- Published
- 2025-05-01
- DOI
- https://doi.org/10.1016/j.jbc.2025.109263
- Primary Topic
- Epigenetics and DNA Methylation
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Institutes of Health
- Lawrence Berkeley National Laboratory