Abstract 2503 Plasmalogens and Lysoplasmalogens are Reduced in Sepsis and Lysoplasmenylethanolamine Supplementation Rapidly Reverses Plasmalogen Loss in Endotoxin-Stimulated Endothelium

Background: Sepsis is characterized by the presence of an infection and a dysregulated host response causing organ dysfunction. Excess oxidative stress is common during sepsis at the blood-endothelium interface. Plasmalogen phospholipids are present in plasma and in cellular membranes and have been shown to provide a benefit as sacrificial antioxidants. Recently, we have found that plasmenylcholines and plasmenylethanolamines are reduced in a cecal slurry rat model of sepsis and in human sepsis.