Abstract 2379 Gene Dosage and Protein Valency Impact Phase Separation and Fungal Cell Fate

Cell fate decisions in eukaryotes are regulated by interconnected networks of transcription factors (TFs) that drive heritable changes in cell identity. However, much is still unknown about how TFs act together to alter cell fate, despite links to cellular dysfunction and disease when TF function is aberrant. Here, we addressed the interplay between network TFs that control heritable switching in the diploid fungal pathogen Candida albicans. This species can propagate in two alternative cell states, white and opaque, with epigenetic transitions between states regulated by a core network of eight TFs plus >100 auxiliary TFs.