Abstract 2002 ADR-2 regulates the germline transcriptome and affects fertility and oocyte fate

RNA-binding proteins (RBPs) play essential roles in coordinating proper gene expression and development in all organisms. Adenosine DeAminases that act on RNA (ADARs) are a class of RBPs that regulate cellular processes at the RNA level by binding to double-stranded RNA (dsRNA) and catalyzing the deamination of Adenosine to Inosine, known as A-to-I RNA editing. Previous work from our lab has shown that ADR-2, the sole A-to-I editing enzyme in Caenorhabditis elegans, can target specific RNAs and produce unique cellular outcomes in different life stages, tissues, and environmental conditions.