Abstract 2313 Changes in Histone Modifications and Epstein-Barr Virus reactivation in Burkitt lymphoma cells due to treatment with ketone bodies

Epstein-Barr Virus (EBV) is a member of the human herpes viruses and is present in upwards of 90% of the human population. EBV is associated with many clinically relevant human diseases, including mononucleosis and is one of the known viruses that have been linked to various human cancers such as Burkitt lymphoma. EBV has a two-phase life cycle and primarily resides in the latent phase, however EBV can reactivate into a lytic phase where it will begin to replicate its viral genome, produce viral progeny, and eventually lyse the host cell to release its progeny into the environment where the infection cycle restarts.