Abstract 2156 Epigenetic Control of Macrophage Inflammatory Activation by the Bromodomain and Extraterminal Domain Proteins

Inflammatory diseases are the leading global cause of mortality. Chronic or dysregulated inflammation is a critical driver in the initiation and progression of these diseases. Prolonged macrophage activation to a proinflammatory state is a primary contributor to dysregulated inflammation through the secretion of proinflammatory cytokines. Here, we determine the roles of the bromodomain and extraterminal domain (BET) protein family in regulating macrophage inflammatory activation. BET proteins (BRD2/3/4/T) contain two tandem bromodomains (BD1 and BD2) that bind acetylated lysine residues on histones and other nuclear proteins.