Abstract 2089 Pioneer transcriptional repression enables macrophage plasticity and adaptation across tissues and inflammatory contexts via BACH1's bimodal activities

The inflammatory response of macrophages (MF) depends on tight transcriptional regulation to ensure proper activation, resolution, and adaptation to diverse tissue environments. While transcriptional activation is well-characterized, the role of active transcriptional repression and bookmarking in controlling macrophage identity, heterogeneity, and function is less understood. Here, we identify BACH1, a heme-regulated transcriptional repressor, as a bimodal critical epigenomic safeguard in macrophages.