Abstract 2390 Remodeling chromatin in cancer

Chromatin remodelers are frequently mutated in cancer, and our understanding of the cellular and physiological consequences of these mutations is beginning to emerge. Melanoma is the most lethal form of skin cancer with rising incidence, and disseminated disease is clinically challenging to treat. ARID2 is the most recurrently mutated SWI/SNF complex member in melanoma, however its tumor suppressive mechanisms in the context of the chromatin landscape remain to be elucidated. Studies will be presented of our ongoing efforts to understand the consequences of chromatin remodeling mutations in cancer, including melanoma and neuroblastoma.