Abstract 1735 Structure & Substrate Specificity of Legionella pneumophila Histone Lysine Methyltransferases
Legionnaires' Disease is a type of bacterial pneumonia that affects tens of thousands of people annually in America, with a 10% fatality rate[1]. Humans contract Legionnaires' Disease by inhaling aerosolized water containing the pathogen Legionella pneumophila, which infects and multiplies within lung macrophages[2]. L. pneumophila secretes over 300 effector proteins through a Type IV secretion system, which hijack various cellular pathways, including the host cells' gene expression and immune response, to facilitate bacterial replication.
Authors
- Mallouki Ben Yamine
- Alexandra Hicks (ORCID: https://orcid.org/0000-0002-0302-5073)
- Silvia González (ORCID: https://orcid.org/0000-0003-3282-9094)
- Emily Xu (ORCID: https://orcid.org/0000-0002-6066-8147)
- Jean‐Marc Fontaine
- K.M. Daniels (ORCID: https://orcid.org/0000-0002-1437-1457)
- Raymond C. Trievel (ORCID: https://orcid.org/0000-0003-3189-8792)
- Sojin An (ORCID: https://orcid.org/0000-0003-4783-4400)
- Thomas J. Knight
Institutions
- Philadelphia College of Osteopathic Medicine (US)
Publication Details
- Journal
- Journal of Biological Chemistry
- Published
- 2025-05-01
- DOI
- https://doi.org/10.1016/j.jbc.2025.109255
- Primary Topic
- RNA modifications and cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Science Foundation
- U.S. Department of Energy
- National Institutes of Health
- Office of Science