Abstract 2434 Autoregulatory mechanism of enzyme activity by the nuclear localization signal of lysine-specific demethylase 1

Lysine-specific histone demethylase 1 (LSD1) modulates transcription through the removal of methyl groups from lysine residues on histone 3 (H3K4Me1/2 or H3K9Me1/2), serving dual roles as a repressor or activator in gene regulation. Integral to its function, the N-terminal region of LSD1, characterized by an absence of structured elements, features a nuclear localization signal (NLS) that spans residues 112 to 117 (RRARAK). This region is rich in post-translational modifications and serves as a crucial node for protein interactions.