Abstract 2426 Metabolism-Driven Epigenetic Reprogramming: Dissecting the Role of Methionine and SAM in Histone Methylation and Heterochromatin Stability

Epigenetic mechanisms are closely linked with metabolism, as many core metabolites function as essential co-substrates for chromatin-modifying enzymes. Changes in diet or cellular pathology cause fluctuations in such metabolites, influencing the ability of enzymes to add or remove histone post-translational modifications (PTMs). Therefore, histone PTMs can function as an integral node connecting metabolism and gene regulation by allowing cells to sense the availability of key metabolites and directly alter gene expression in real time.