Abstract 2487 EZH2-mediated epigenetic regulation of glycosaminoglycan biosynthesis modulates melanoma cell growth and invasion

Glycosaminoglycans (GAGs) are sulfated polysaccharides ubiquitously expressed on all animal cells and are attached to core proteins, known as proteoglycans, on the cell surface and extracellular matrix (ECM). GAG chains are composed of alternating amino sugars and uronic acids that are heterogeneously N- and O-sulfated, enabling key interactions with various extracellular signaling molecules and other ligands that are crucial to maintaining proper cell growth and homeostasis. Dysregulation of GAG expression and assembly has been implicated in the progression of various cancers, including melanoma.