Abstract 1382 Telithromycin impact on transcription and translation via whole mRNA sequencing and direct ribosome profiling in cyanobacterium Synechocystis sp. PCC 6803

Synechocystis sp. PCC 6803 is a model cyanobacterium that accumulates poly(3-hydroxybutyrate) (PHB) under nitrogen-limiting conditions. Curiously, under nitrogen-replete growth conditions, inhibiting protein synthesis with subinhibitory concentrations of the antibiotic chloramphenicol slightly increased PHB accumulation with minimal impact on growth yield. To expand on this observation, we investigated a panel of 25 antibiotics on PHB accumulation in Synechocystis under nitrogen-replete growth conditions.