Abstract 1179 Oligomerization of Collagen Lysyl Hydroxylases regulates their functions

Collagen, the most abundant protein in vertebrates, serves as the building block for connective tissues, such as the vasculature, bone, and skin. What allows collagen to function properly in these different connective tissues is the hydroxylation and glycosylation of lysine residues. In humans, bifunctional enzymes named lysyl hydroxylases (LH1-3) catalyze the collagen lysyl hydroxylation and glucosylation modifications. The importance of LH-mediated collagen post-translational modifications is emphasized by human diseases.