Abstract 2443 Fluctuations in central metabolite availability regulate global and site-specific chromatin mechanisms
Central metabolites function as essential cosubstrates for chromatin modifying enzymes, directly linking cellular metabolism to chromatin regulation. Accordingly, dynamic changes in the global availability of these metabolites have been observed to influence downstream phenotypes through chromatin-dependent mechanisms. We have previously shown how dietary or in vitro restriction of the essential amino acid methionine leads to decreased availability of its downstream product S-adenosylmethionine (SAM), the universal methyl-donor of the cell.
Authors
- Irene M. Ong (ORCID: https://orcid.org/0000-0002-9353-6941)
- Dudley W. Lamming (ORCID: https://orcid.org/0000-0002-0079-4467)
- Krittisak Chaiyakul (ORCID: https://orcid.org/0000-0001-8797-880X)
- Spencer A. Haws (ORCID: https://orcid.org/0000-0002-2166-1858)
- Cara L. Green (ORCID: https://orcid.org/0000-0002-2293-9364)
- Laurence J. Miller (ORCID: https://orcid.org/0000-0002-4554-3872)
- John M. Denu (ORCID: https://orcid.org/0000-0001-9415-0365)
- Yang Liu (ORCID: https://orcid.org/0000-0002-4989-2404)
Institutions
- University of Wisconsin–Madison (US)
Publication Details
- Journal
- Journal of Biological Chemistry
- Published
- 2025-05-01
- DOI
- https://doi.org/10.1016/j.jbc.2025.109525
- Primary Topic
- Metabolism and Genetic Disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00