Abstract 2292 GATAD2B O-GlcNAcylation regulates breast cancer stem-like potential and drug resistance

The growth of breast tumors is driven and controlled by a subpopulation of cancer cells resembling adult stem cells, which are called cancer stem-like cells (CSCs). In breast cancer, the function and maintenance of CSCs are influenced by protein O-GlcNAcylation and the enzymes responsible for this post-translational modification, O-GlcNAc transferase (OGT) and O-GlcNAcase (OGA). The mechanism(s) by which elevated O-GlcNAc modification regulates CSCs in breast cancer are still unclear. Proteomic analysis showed increased expression of components of the Nucleosome Remodeling and Deacetylase (NuRD) complex in response to elevated protein O-GlcNAc modification.