Abstract 1885 Exploring the Human Glycome using Smart Anti-Glycan Reagents (SAGRs)
Glycans are essential mediators of numerous physiological and pathological processes. Recent advancements in high-throughput mass spectrometry and genetic screening have significantly enhanced our understanding of glycan function and their abnormal expression patterns during development and disease. However, the expression and spatial localization of glycans in human tissues remains poorly understood due to the scarcity of monoclonal antibodies (mAbs) targeting carbohydrate antigens. To overcome this limitation, we developed a novel library of Smart Anti-Glycan Monoclonal Antibodies (SAGRs) aimed at elucidating the human glycome.
Authors
- Ea Kristine Clarisse Tulin (ORCID: https://orcid.org/0000-0002-8889-5317)
- Richard D. Cummings (ORCID: https://orcid.org/0000-0002-8918-5034)
- Lauren E. Pepi (ORCID: https://orcid.org/0000-0002-5740-4175)
- Tianwei Jia (ORCID: https://orcid.org/0009-0007-1931-9010)
- Maxence Noël (ORCID: https://orcid.org/0000-0003-2621-7374)
- Lukas Muerner
- Jamie Heimburg‐Molinaro (ORCID: https://orcid.org/0000-0003-4987-3016)
- Tanya R. McKitrick (ORCID: https://orcid.org/0000-0002-1312-6089)
- Catherine Tilton
Institutions
- Deaconess Hospital (US)
- Beth Israel Deaconess Medical Center (US)
Publication Details
- Journal
- Journal of Biological Chemistry
- Published
- 2025-05-01
- DOI
- https://doi.org/10.1016/j.jbc.2025.109329
- Primary Topic
- Glycosylation and Glycoproteins Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00