Abstract 1656 Transient Inhibition of Serum Amyloid A Suppresses the Expansion of Triple Negative Breast Cancer (TNBC) Stem Cell population

Acquisition and maintenance of cancer stem cells (CSCs) affects all stages of tumorigenesis. Enhanced cancer stemness is shown to promote cancer invasion and metastasis and is favored by altered metabolic states like hyperglycemia in Type II Diabetes (T2D). Women with a history of T2D have a reported 38% increased odds of TNBC, a therapeutically defiant subtype of breast cancer that has a high likelihood of metastasis. Our preliminary data with RNA-seq analysis of TNBC enriched CSC under hyperglycemic conditions indicated an increase in the expression of pro-inflammatory proteins, Serum amyloid A1 and A2 (SAA1/A2) by 3.5 ± 0.72 folds.