Abstract 1687 The Effect of Fatty Acid Synthase Inhibition on mTOR Signaling in Colorectal Cancer

Cancer cells undergo metabolic alterations to support their increasing needs for growth and proliferation. Fatty acid synthase, FASN, a key enzyme in the fatty acid biosynthesis pathway responsible for convering acetyl-CoA and malonyl-CoA to palmitate is frequently upregulated in cancer. Previous studies have shown that upregulation of FASN and de novo lipid biosynthesis promote tumor progression and metastasis, thus providing a strong rationale for targeting FASN using small molecule inhibitors for cancer therapy.