Abstract 1915 NHE9 Modulates Exosome Communication to Enhance Macrophage-Mediated Cardiomyocyte Repair under Oxidative Stress

Oxidative stress is a key factor in the progression of cardiovascular diseases, severely damaging cardiomyocytes. Cardiomyocyte repair post-oxidative stress is heavily reliant on communication with macrophages, which are crucial for tissue repair and inflammation modulation. This intercellular communication is facilitated by exosomes, which are small vesicles ranging from 30 to 150 nm in size that transfer molecular cargo affecting macrophage functions. Understanding the regulation of exosome release and being able to modulate their output is vital for advancing therapeutic applications and improving the repair process.