Abstract 1585 Identification of translocon-associated protein subunit beta (TRAPβ) as a regulator of cell cycle progression and apoptosis in human colorectal cancer cells
Translocon-associated protein subunit beta (TRAPβ), also known as signal sequence receptor 2 (SSR2) facilitates co-translational translocation in the endoplasmic reticulum (ER); however, its role in colorectal cancer is not comprehended yet. This study was conducted to examine the biological role of TRAPβ/SSR2 in the proliferation phenotype of human colorectal cancer cells. Transient knockdown of TRAPβ/SSR2 gene with small interfering ribonucleic acid (siRNA) significantly suppressed the viability of SW480, HCT116, and DLD-1 cells.
Authors
- Seong‐Ho Lee (ORCID: https://orcid.org/0000-0001-5876-1396)
- Darshika Amarakoon (ORCID: https://orcid.org/0000-0003-3651-0435)
- Cheng–I Wei (ORCID: https://orcid.org/0000-0001-9764-3181)
- Jing Peng (ORCID: https://orcid.org/0009-0006-8296-2052)
Institutions
- University of Maryland, College Park (US)
Publication Details
- Journal
- Journal of Biological Chemistry
- Published
- 2025-05-01
- DOI
- https://doi.org/10.1016/j.jbc.2025.108666
- Primary Topic
- Cell death mechanisms and regulation
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- U.S. Department of Agriculture
- Northwest Fisheries Science Center