Abstract 2150 Dual inhibition of SWI/SNF ATPases BRG1/BRM impairs DNA end resection and homologous recombination, sensitizes cells to DNA damage and PARP inhibitors, and activates the cGAS/STING response

SWI/SNF chromatin remodelers are large multi-subunit complexes that modulate chromatin accessibility and are mutated in up to 20% of cancers. These complexes contain two mutually exclusive ATPases, BRG1 and BRM. While these complexes are important for transcription regulation, we showed that SWI/SNF chromatin remodelers also play a role in the repair of DNA double strand breaks (DSB). It is important to identify which subunits within the SWI/SNF complexes are important for this function in DNA repair, as that would identify DNA repair vulnerabilities in SWI/SNF-mutated cancers that can be exploited therapeutically.