Abstract 2241 Metabolically Activated Macrophages and Their Role in Radiation-Induced Breast Cancer Recurrence

Triple-negative breast cancer (TNBC) is an aggressive subtype of breast cancer characterized by a high likelihood of locoregional recurrence. This study explores how macrophages, specifically those with a metabolically activated (MMe) phenotype, behave after radiation damage and contribute to cancer recurrence. Macrophages are key immune cells that help defend the body against infections and cancer. In adipose tissue, these macrophages help regulate metabolism, but in obesity, they become metabolically activated, leading to increased inflammation and the ability to clear dead fat cells.