Abstract 1480 Eeyarestatin I (ESI) Stimulates JNK-dependent G2/M Arrest and Apoptosis and Downregulates Expression of Translocon-associated Proteins (TRAPs) in Human Colorectal Cancer Cells
Eeyarestatin I (ESI) is a small molecule that inhibits endoplasmic reticulum-associated protein degradation (ERAD) and Sec61-dependent cotranslational translocation in endoplasmic reticulum (ER) membrane. In the current study, for the first time we examined the anti-cancer activity of ESI and elucidated the underlying anti-cancer mechanisms in human colorectal carcinoma cells. The treatment of ESI repressed the viability of diverse types of human colorectal cancer cells in a dose-dependent manner.
Authors
- Seong‐Ho Lee (ORCID: https://orcid.org/0000-0001-5876-1396)
- Cheng–I Wei (ORCID: https://orcid.org/0000-0001-9764-3181)
- Jing Peng (ORCID: https://orcid.org/0009-0006-8296-2052)
Institutions
- University of Maryland, College Park (US)
Publication Details
- Journal
- Journal of Biological Chemistry
- Published
- 2025-05-01
- DOI
- https://doi.org/10.1016/j.jbc.2025.108657
- Primary Topic
- Cytokine Signaling Pathways and Interactions
- Type
- article
- Field-Weighted Citation Impact
- 0.00